BiOptimizer Scientific Studies:
Evidence Supporting Every Formula

Access the clinical and laboratory studies that validate each BiOptimizers product, demonstrating its effectiveness in digestive health, energy, sleep and microbiome.

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Magnesium Breakthrough

The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial

Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B.
Herbal Power Flush

Studies on the role of intestinal bacteria in metabolism of synthetic and natural steroid hormones

Adlercreutz H, Pulkkinen MO, Hämäläinen EK, Korpela JT.
Berberine Breakthrough

Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome

Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM.
Berberine Breakthrough

Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome

Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM.
Berberine Breakthrough

Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome

Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM.
Cognibiotics

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

Allen J, Romay-Tallon R, Brymer KJ, Caruncho HJ, Kalynchuk LE.
Magnesium Breakthrough Drink

Effects of Magnesium Supplementation on Blood Pressure

American Heart Association
Magnesium Breakthrough Drink

Magnesium in Man: Implications for Health and Disease

American Physiological Society
MassZymes

Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?.

André P, Laugerette F, Féart C.
Magnesium Breakthrough

Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial

Asemi Z, Karamali M, Jamilian M, et al.
Magnesium Breakthrough

The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials

Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M.
Gluten Guardian

Ehren J, Morón A food-grade enzyme preparation with modest gluten detoxification properties

B, Martin E, Bethune MT, Gray GM, Khosla C.
Magnesium Breakthrough Drink

Effects of magnesium citrate

BMC Trials
Probiotic Breakthrough

Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis

Bajaj JS, Heuman DM, Hylemon PB, et al.
Gluten Guardian

Properties of Gluten Intolerance: Gluten Structure, Evolution, Pathogenicity and Detoxification Capabilities

Balakireva AV, Zamyatnin AA
Magnesium Breakthrough

Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial

Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F.
MassZymes

Effects of a protease supplement on eccentric exercise-induced markers of delayed-onset muscle soreness and muscle damage

Beck TW, Housh TJ, Johnson GO, et al.
Berberine Breakthrough

The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-γ)

Beekmann K, Rubió L, de Haan LH, et al.
Probiotic Breakthrough

Probiotic Mechanisms of Action

Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A.
MassZymes

Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging

Blair MJ, Jones JD, Woessner AE, Quinn KP.
Para Guardian

Tropical worms: they infect a third of the planet, so why aren’t we doing more? The Conversation

Booth M.
Magnesium Breakthrough

The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review

Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P.
Probiotic Breakthrough

Metabolic endotoxemia with obesity: Is it real and is it relevant?

Boutagy NE, McMillan RP, Frisard MI, Hulver MW.
Magnesium Breakthrough

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review

Boyle NB, Lawton C, Dye L.
Magnesium Breakthrough

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review

Boyle NB, Lawton C, Dye L.
Magnesium Breakthrough

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review

Boyle NB, Lawton C, Dye L.
Cognibiotics

The gut microbiota influences blood-brain barrier permeability in mice

Braniste V, Al-Asmakh M, Kowal C, et al.
Gluten Guardian

Systematic Review of the Gastrointestinal Effects of A1 Compared with A2 β-Casein

Brooke-Taylor S, Dwyer K, Woodford K, Kost N.
Magnesium Breakthrough

Bioavailability of oral magnesium supplementation in female students evaluated from elimination of magnesium in 24-hour urine

Bøhmer T, Røseth A, Holm H, Weberg-Teigen S, Wahl L.
Magnesium Breakthrough

Sanofi Internal report MAB6-32

Caillard, V. (1992).
Cognibiotics

Gut permeability and depressive symptom severity in unmedicated adolescents

Calarge CA, Devaraj S, Shulman RJ.
Magnesium Breakthrough

Magnesium and osteoporosis: current state of knowledge and future research directions

Castiglioni S, Cazzaniga A, Albisetti W, Maier JA.
Cognibiotics

Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health

Chambers ES, Preston T, Frost G, Morrison DJ.
Berberine Breakthrough

Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells

Chao CY, Huang CJ.
Para Guardian

Preventive effects and mechanisms of garlic on dyslipidemia and gut microbiome dysbiosis

Chen K, Xie K, Liu Z, et al.
Probiotic Breakthrough

Probiotic Lactobacillus rhamnosus GG reduces mortality of septic mice by modulating gut microbiota composition and metabolic profiles

Chen L, Li H, Chen Y, Yang Y.
Herbal Power Flush

The gut microbiota is a major regulator of androgen metabolism in intestinal contents

Colldén H, Landin A, Wallenius V, et al.
Para Guardian

Enteric nematodes of humans. In: Baron S, ed.

Cross JH.
Cognibiotics

The Microbiota-Gut-Brain Axis

Cryan JF, O'Riordan KJ, Cowan CSM, et al.
Cognibiotics

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

Dehhaghi M, Kazemi Shariat Panahi H, Guillemin GJ.
Herbal Power Flush

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

Dehhaghi M, Kazemi Shariat Panahi H, Guillemin GJ.
Probiotic Breakthrough

Probiotics and functional abdominal bloating

Di Stefano M, Miceli E, Armellini E, Missanelli A, Corazza GR.
Magnesium Breakthrough

Magnesium for the prevention and treatment of cardiovascular disease

DiNicolantonio JJ, Liu J, O'Keefe JH.
Magnesium Breakthrough Drink

Magnesium and mental health

Diasporal
Magnesium Breakthrough Drink

What is Chelated Magnesium (chelated magnesium)?

Drugs.com
Magnesium Breakthrough

Rapid recovery from major depression using magnesium treatment

Eby GA, Eby KL
Herbal Power Flush

Bowel transit time: MedlinePlus Medical Encyclopedia

Encyclopedia M, time B.
Magnesium Breakthrough Drink

Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial

Europe PMC
Gluten Guardian

All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases

Fasano A.
Probiotic Breakthrough

Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

Fasano A. Yong SJ, Tong T, Chew J, Lim WL.
Cognibiotics

Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review

Feng DD, Tang T, Lin XP, et al.
Magnesium Breakthrough

Bioavailability of US commercial magnesium preparations

Firoz M, Graber M.
Para Guardian

Enteric protozoa in the developed world: a public health perspective

Fletcher SM, Stark D, Harkness J, Ellis J.
Kapex

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol

Foretz M, Viollet B.
Cognibiotics

A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity

Fukuda S, Nojima J, Motoki Y, et al.
Berberine Breakthrough

Sea Buckthorn Fruit Oil Extract Alleviates Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Cells and Rats

Gao S, Guo Q, Qin C, Shang R, Zhang Z.
HCL Breakthrough

Small Intestinal Bacterial Overgrowth and Digestive problems: A Bridge between Functional Organic Dichotomy

Ghoshal UC, Shukla R, Ghoshal U.
Magnesium Breakthrough Drink

Vitamin D and magnesium

GoodRx
Magnesium Breakthrough

Anxiety and stress among science students. Study of calcium and magnesium alterations

Grases G, Pérez-Castelló JA, Sanchis P, et al.
Magnesium Breakthrough

Oral magnesium supplementation improves sensitivity in non-diabetic subjects with resistance. A double-blind placebo-controlled randomized trial

Guerrero-Romero F, Tamez-Perez HE, González-González G, et al.
Kapex

Meal-Time Supplementation with Betaine HCl for Functional Hypochlorhydria: What is the Evidence?

Guilliams TG, Drake LE.
Para Guardian

Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats

Hang X, Zhao Y, Zhang M, et al.
Probiotic Breakthrough

Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation

Hemarajata P, Versalovic J.
Berberine Breakthrough

Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, glucose-dependent polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects

Hlebowicz J, Hlebowicz A, Lindstedt S, et al.
Magnesium Breakthrough Drink

How low magnesium affects your blood sugar

Holland & Barrett
Cognibiotics

Effect of Chinese Herbal Medicine on Alzheimer's Disease

Howes MR, Fang R, Houghton PJ.
Berberine Breakthrough

Hypoglycemic herbs and their action mechanisms

Hui H, Tang G, Go VL.
Magnesium Breakthrough

Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study

Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A.
Herbal Power Flush

The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls

Jalanka J, Major G, Murray K, et al.
Kapex

A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults

Kaiman DS, Colker CM, Swain MA, Torina GC, Shi Q.
Berberine Breakthrough

Bioactive fraction from Lagerstroemia speciosa leaves (DLBS3733) reduces fat droplet by inhibiting adipogenesis and lipogenesis

Karsono AH, Tandrasasmita OM, Tjandrawinata RR.
Cognibiotics

Is Your Mood Disorder a Symptom of Unstable Blood Sugar?

Kay, MPH, RDN I.
Cognibiotics

HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition

Keller J, Gomez R, Williams G, et al.
Magnesium Breakthrough

Magnesium intake in relation to systemic inflammation, resistance, and the incidence of diabetes

Kim DJ, Xun P, Liu K, et al.
Berberine Breakthrough

AMPK activators: mechanisms of action and physiological activities

Kim J, Yang G, Kim Y, Kim J, Ha J.
Para Guardian

Inflammation and gastrointestinal Candida colonization

Kumamoto CA.
Berberine Breakthrough

Stimulatory Effects of Cinnamon Extract (Cinnamomum cassia) during the Initiation Stage of 3T3-L1 Adipocyte Differentiation

Lee SG, Siaw JA, Kang HW.
Magnesium Breakthrough Drink

Timeline (Bioavailability) of Magnesium Compounds in Hours

Library of Medicine
Cognibiotics

Gut Microbiome and Depression: How Microbes Affect the Way We Think

Limbana T, Khan F, Eskander N.
Berberine Breakthrough

Hot Flashes Linked to Resistance

Lowry, F., 2012.
HCL Breakthrough

Digestive problems, anxiety, and depression: what are the links?

Lydiard RB.
MassZymes

Correlation of intestinal permeability with exocrine pancreatic dysfunction

Mack DR, Flick JA, Durie PR, Rosenstein BJ, Ellis LE, Perman JA.
Berberine Breakthrough

Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: a review

Maeda H.
Kapex

Hepatoprotection by dandelion (Taraxacum officinale) and mechanisms

Mahboubi M, Mahboubi M.
Probiotic Breakthrough

Effects of probiotics, prebiotics, and synbiotics on human health

Markowiak P, Śliżewska K.
Probiotic Breakthrough

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

Markowiak-Kopeć P, Śliżewska K.
MassZymes

Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial

Marzin T, Lorkowski G, Reule C, et al.
Kapex

Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial

Marzin T, Lorkowski G, Reule C, et al.
Magnesium Breakthrough Drink

Sucrosomial Magnesium: A source of magnesium oxide with superior bioavailability

Maypro
Magnesium Breakthrough Drink

Metabolic supplementation with orotic acid and magnesium orotate

Metabolic supplementation with orotic acid and magnesium orotate National Library of Medicine
Cognibiotics

The gut microbiota-brain axis in behaviour and brain disorders.

Morais, L. H., Schreiber, H. L., 4th, & Mazmanian, S. K. (2020).
Magnesium Breakthrough

Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women

Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B.
Magnesium Breakthrough Drink

Complementary vascular-protective actions

National Library of Medicine
Magnesium Breakthrough Drink

Superiority of magnesium and vitamin B6

National Library of Medicine
Magnesium Breakthrough Drink

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

National Library of Medicine
Magnesium Breakthrough Drink

Can Magnesium Enhance Exercise Performance?

National Library of Medicine
Magnesium Breakthrough Drink

The Effects of Magnesium Supplementation on Subjective Anxiety and Stress

National Library of Medicine
Magnesium Breakthrough Drink

A connection between magnesium deficiency and aging: new insights from cellular studies

National Library of Medicine
Magnesium Breakthrough Drink

Magnesium and chronic inflammationImpact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race

National Library of Medicine
Magnesium Breakthrough Drink

The effect of magnesium supplementation

National Library of Medicine